17-2022-IMT PhD Position: Microfluidic systems for high throughput NMR and process monitoring
Institut für Mikrostrukturtechnik (IMT)
You will join the collaborative research center (CRC) 1527 High performance compact magnetic resonance (HyPERiON), which aims to change the future of magnetic resonance (MR) by exploring the limits of extremely compact, highly sensitive, high throughput, and highly agile MR systems. The CRC is funded by the DFG (Deutsche Forschungsgemeinschaft), and is a collaboration between 16 research groups in the Karlsruhe Institute of Technology, the Technical University of Kaiserslautern, the University of Konstanz, and the University of Stuttgart.
KIT offers a research-friendly environment and being part of the KIT, you will have the possibility to join one of the graduate schools and benefit from its services and advantages. IMT is additionally well equipped in research facilities and equipment. You will have access to an X-band EPR system and several low-field and state-of-the-art high-field NMR and MRI systems. Furthermore, you will have access to several labs for micro-manufacturing, prototyping, electronics and RF characterization, optics, fluidics, chemistry, and biology.
For this position, you will investigate novel microfluidic systems compatible with NMR measurement of biological systems. As MR systems become more compact, novel approaches to sample handling will be needed. This can be facilitated by a transition from sample glass tubes to a microfluidic approach, with the added benefit of having a large library of available microfluidic technologies to access new approaches to NMR measurement. The objective of this project will be to implement a compact MR sample system compatible with biofilm monitoring. The system must enable fluid flow for nutrient exchange together with electrochemical and light interaction with the sample, while maintaining high NMR spectroscopic quality. This project will be in close collaboration with a second doctoral researcher responsible for implementing the biofilm experiment within the microfluidic system. To accomplish the project objectives, you will address the following tasks:
- Design and fabricate a microfluidic platform satisfying bio- and MR-compatibility. Biocompatibility will be addressed together with the second doctoral researcher.
- Implement electrochemical sample interaction with the microfluidic platform. This task will take advantage of our group’s experience in integrated interdigitated electrodes and electrochemistry electrodes for sample interaction.
- Implement optical elements for sample interaction with the microfluidic platform. This task will aim to integrate light into the microfluidic sample chamber to enable various optical experiments. Targeted wavelengths are in the 350 – 700 nm range.
- Functional verification of the platform. With each interaction modality, functionality must be verified, including bio- and MR-compatibility. These experiments will be done in collaboration with the second doctoral researcher.
as soon as possible
- M.Sc. in Mechanical Engineering, Electrical Engineering, or Physics
- Enthusiastic to work in a highly interdisciplinary environment
- Experience in at least two of the following: microfluidic design and fabrication, NMR spectroscopy, cleanroom fabrication, optics
limited to 3 years
Application up to
October 16, 2022
Contact person in line-management
For further information, please contact Dr. Neil MacKinnon, email: email@example.com
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