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34-2020-IMT PhD Position: In situ correlation of optical imaging with NMR microscopy, towards movement compensated metabolomic imaging of model organisms

Organizational unit

Institute of Microstructure Technology (IMT)

Job description

The aim of this joint doctoral project is to combine microscopy with NMR (Nuclear Magnetic Resonance) analysis of microscopic samples. This shall enable us to perform NMR analysis of freely moving small organisms. When microorganisms are retained, their metabolomic response differs significantly from that of free organisms, so that they are of little significance in biological experiments. However, when NMR signals from freely moving organisms are detected, the accuracy of the information is distorted or destroyed. These conflicting requirements call for a new strategy in NMR characterization.

The goal is to adjust the intrinsic magnetic coordinate system of an NMR magnet in real time so that any captured NMR signal can be treated as if it were from a stationary object. One way to achieve this is to correlate an MR-compatible ultra-compact optical microscope with the NMR environment and to merge the two information datasets using a combination of image processing, motion prediction, coordinate transformation, and pulse sequence control. In addition to developing appropriate object tracking methods, the NMR detector must also be adapted to allow sensitive signal acquisition over a wider experimental range, for example, through the use of a phased coil array. Foundations for the miniaturized MR-compatible microscope have been implemented in the Laboratory for Micaroactuators at IMTEK, whereas the micro NMR detectors belong to the expertise of Prof. Korvink, head of the Microsystems Department IMT of KIT.

Starting date

as soon as possible

Personal qualification

  • University degree (Diploma (UNI) / Master) in micro systems engineering, physics, mechanical engineering, or electrical engineering with an above average grade
  • Basic physical and engineering knowledge, if possible knowledge in optics and/or microscopic and spectroscopic characterization methods and image processing
  • Experience in micro fabrication methods
  • Analytical skills to solve physical and technical issues
  • Interest in computer science and biological issues
  • Good English and preferably German communication skills

Contract duration

limited to 3 years

Application up to

15.02.2021

Contact person in line-management

For further information, please contact Prof. Dr. Korvink, e-mail: jan.korvink@kit.edu, phone 0721 608-22740

Please apply online using the button below for this vacancy number 34-2020-IMT.

Ausschreibungsnummer: 34-2020-IMT

Recognized severely disabled persons will be preferred if they are equally qualified.

Contact

Personnel Support is provided by:
Ms Gätcke
Phone: +49 721 608-25010,

Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany